Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203993 | 0.92 | MAPT (0.49) | MAPTALDH1A1HTR6MAPK1TDP1 | |
| SCHEMBL8139111 | 0.85 | MAPT (0.47) | MAPTALDH1A1HTR6MAPK1GAA | |
| SCHEMBL8203184 | 0.82 | BRD4 (0.56) | MAPTALDH1A1HTR6 | |
| SCHEMBL8201947 | 0.78 | ALDH1A1 (0.45) | MAPTALDH1A1GSTM2MAPK1LMNA | |
| SCHEMBL7814569 | 0.77 | LMNA (0.51) | MAPTALDH1A1MAPK1LMNA | |
| SCHEMBL27807398 | 0.75 | GRIA1 (0.49) | MAPTIDO1LMNA | |
| SCHEMBL29486349 | 0.74 | ENPP2 (0.50) | MAPTIDO1LMNA | |
| SCHEMBL14155094 | 0.73 | GSTM2 (0.54) | MAPTALDH1A1GSTM2KAT2BMAPK1 | |
| SCHEMBL8203750 | 0.73 | GSTM2 (0.54) | MAPTALDH1A1GSTM2KAT2BTDP1 | |
| SCHEMBL17743378 | 0.72 | GSTM2 (0.54) | MAPTALDH1A1GSTM2KAT2BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121264-A | GLUTAMATE RECEPTOR ANTAGONIST, AMPA RECEPTOR ANTAGONIST, NMDA-GLYCINE RECEPTOR ANTAGONIST, KAINIC ACID NEUROTOXICITY INHIBITOR, ANTIISCHEMIC AGENT, PSYCHOTROPIC AGENT | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-0919554-A1 | IMIDAZOLE-SUBSTITUTED QUINOXALINEDIONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1999-06-02 | — | — | EP | disclosed |