SCHEMBL8205134

SCHEMBL8205134

CC(=O)NC(=O)Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.50
TSHR P16473 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
LMNA P02545 2/20 0.48
MAPT P10636 2/20 0.48
HTT P42858 2/20 0.48
LOXL2 Q9Y4K0 1/20 0.48
POLB P06746 1/20 0.48
SIGMAR1 Q99720 3/20 0.47
MAOB P27338 1/20 0.47
PIK3CA P42336 1/20 0.46
ALDH1A1 P00352 1/20 0.46
TRPV1 Q8NER1 1/20 0.46
KCNQ2 O43526 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7415754 0.82 TSHR (0.53) L3MBTL1TSHRSMN1; SMN2CA1CA2
SCHEMBL8207778 0.80 ALDH1A1 (0.57) L3MBTL1SMN1; SMN2MEN1KMT2ALMNA
SCHEMBL13485812 0.80 MEN1 (0.52) L3MBTL1TSHRMEN1KMT2ALMNA
SCHEMBL1136782 0.80 TSHR (0.53) L3MBTL1TSHRSMN1; SMN2CA2KMT2A
SCHEMBL1203812 0.79 LOXL2 (0.54) L3MBTL1TSHRSMN1; SMN2CA1CA2
SCHEMBL13683247 0.77 TSHR (0.65) TSHRSMN1; SMN2CA1CA2MEN1
SCHEMBL14310922 0.77 CA2 (0.65) L3MBTL1TSHRSMN1; SMN2CA1CA2
SCHEMBL8195021 0.77 ACLY (0.44) L3MBTL1SMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL21980988 0.76 HTT (0.56) L3MBTL1CA1CA2MEN1KMT2A
SCHEMBL30776879 0.76 HTT (0.56) L3MBTL1CA1CA2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6093851-A N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2000-07-25 US disclosed
EP-0735018-B1 N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL CO (JP) 1999-07-21 EP disclosed
US-5739401-A N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-04-14 US disclosed
EP-0735018-A1 N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-10-02 EP disclosed