Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22219971 | 0.86 | CA2 (0.69) | CA1CA2SIGMAR1PIK3CA | |
| SCHEMBL18475760 | 0.86 | CA2 (0.53) | CA1CA2POLBTRPV1 | |
| SCHEMBL26660399 | 0.84 | PIK3CA (0.52) | TSHRCA1CA2MAPTALDH1A1 | |
| SCHEMBL13485812 | 0.83 | MEN1 (0.52) | TSHRL3MBTL1MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL26660393 | 0.83 | PIK3CA (0.51) | TSHRCA1CA2SMN1; SMN2MAPT | |
| SCHEMBL28190396 | 0.82 | PYGL (0.65) | TSHRSMN1; SMN2ALDH1A1SIGMAR1TRPV1 | |
| SCHEMBL30791548 | 0.82 | PYGL (0.65) | TSHRSMN1; SMN2ALDH1A1SIGMAR1TRPV1 | |
| SCHEMBL8205134 | 0.82 | L3MBTL1 (0.50) | TSHRL3MBTL1CA1CA2SMN1; SMN2 | |
| SCHEMBL1203812 | 0.81 | LOXL2 (0.54) | TSHRL3MBTL1CA1CA2SMN1; SMN2 | |
| SCHEMBL13683247 | 0.80 | TSHR (0.65) | TSHRCA1CA2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250537-A | Treating psychoses | SCIOS NOVA INC. (US) | 1993-10-05 | — | — | US | claimed |
| EP-3016950-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9663529-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663529-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160152627-A1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-06-02 | — | — | US | disclosed |
| US-20160152627-A1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-06-02 | — | — | US | disclosed |
| EP-2623123-A1 | Oligomer-opioid agonist conjugates | Nektar Therapeutics (US) | 2013-08-07 | — | — | EP | disclosed |
| US-7902330-B2 | Protein kinase inhibitors and methods for identifying same | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902330-B2 | Protein kinase inhibitors and methods for identifying same | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2011-03-08 | — | — | US | disclosed |
| US-20100113371-A9 | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds | RANBAXY LABORATORIES LIMITED INC. (IN) | 2010-05-06 | — | — | US | disclosed |
| US-20100113371-A9 | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds | RANBAXY LABORATORIES LIMITED INC. (IN) | 2010-05-06 | — | — | US | disclosed |
| US-20090075909-A1 | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds | RANBAXY LABORATORIES LIMITED INC. (IN) | 2009-03-19 | — | — | US | disclosed |
| US-20090075909-A1 | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds | RANBAXY LABORATORIES LIMITED INC. (IN) | 2009-03-19 | — | — | US | disclosed |
| US-20070254312-A1 | Protein Kinase Inhibitors and Methods for Identiying Same | NATIONAL INSTITUTES OF HEALTH | 2007-11-01 | — | — | US | disclosed |
| US-20070254312-A1 | Protein Kinase Inhibitors and Methods for Identiying Same | NATIONAL INSTITUTES OF HEALTH | 2007-11-01 | — | — | US | disclosed |
| WO-2005079300-A2 | PROTEIN KINASE INHIBITORS AND METHODS FOR IDENTIFYING SAME | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2005-09-01 | — | — | WO | disclosed |
| US-5436244-A | Antiarrhythmia agents | ROUSSEL UCLAF (FR) | 1995-07-25 | — | — | US | disclosed |
| US-5348971-A | Indanes useful as analgesics | ROUSSEL UCLAF (FR) | 1994-09-20 | — | — | US | disclosed |
| US-5250537-A | Treating psychoses | SCIOS NOVA INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0374054-A1 | Indane derivatives, process for their preparation and intermediates obtained, their use as medicines, and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1990-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075909-A1 | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds | HLA-DRB1, IL5, TNF | TSHR 3110/4885L3MBTL1 3651/4885CA1 2344/4885 |
| US-20070254312-A1 | Protein Kinase Inhibitors and Methods for Identiying Same | PRKCA, PRKCE, PRKCB | TSHR 3864/4885L3MBTL1 1537/4885CA1 3416/4885 |
| US-20160152627-A1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | MYLK, MYLK2, ROCK1 | TSHR 2274/4885L3MBTL1 4486/4885CA1 1648/4885 |
| US-20100113371-A9 | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds | HLA-DRB1, IL5, TNF | TSHR 3110/4885L3MBTL1 3651/4885CA1 2344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.