Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208794 | 0.86 | HDAC6 (0.53) | ESRRGLMNAALDH1A1MAPK1SLC22A2 | |
| SCHEMBL8213824 | 0.83 | MAPT (0.55) | LMNAALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9344489 | 0.76 | KDM4E (0.68) | ESRRGLMNAALDH1A1MAPK1SLC22A2 | |
| SCHEMBL20813616 | 0.74 | DGAT1 (0.31) | — | |
| SCHEMBL853302 | 0.74 | HPGD (0.66) | ESRRGLMNAALDH1A1MAPK1SLC22A2 | |
| SCHEMBL8211586 | 0.73 | HDAC6 (0.48) | ESRRGLMNAALDH1A1MAPK1SLC22A2 | |
| SCHEMBL750337 | 0.73 | ESRRG (0.56) | ESRRGLMNAALDH1A1MAPK1SLC22A2 | |
| SCHEMBL19938019 | 0.72 | MLYCD (0.67) | ESRRGLMNAALDH1A1MAPK1SLC22A2 | |
| SCHEMBL23222134 | 0.72 | LMNA (0.61) | ESRRGLMNAALDH1A1MAPK1SLC22A2 | |
| SCHEMBL14066862 | 0.72 | HDAC3 (0.58) | ESRRGLMNAALDH1A1MAPK1SLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033744-A2 | DNA METHYL TRANSFERASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |