Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.51 |
| ▸ | NHERF1 | O14745 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PYGL | P06737 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3043508 | 0.88 | PTPN1 (0.51) | NPC1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL5733671 | 0.84 | RAB9A (0.62) | NPC1HPGDKDM4EMAPTKMT2A | |
| SCHEMBL8204182 | 0.83 | NHERF1 (0.60) | SMAD3NHERF1NPC1HPGDKDM4E | |
| SCHEMBL3058666 | 0.82 | KDM4E (0.62) | NHERF1NPC1HPGDKDM4EMAPT | |
| SCHEMBL7470448 | 0.82 | SMAD3 (0.60) | SMAD3NHERF1NPC1HPGDKDM4E | |
| SCHEMBL8197851 | 0.82 | SMAD3 (0.60) | SMAD3NHERF1NPC1HPGDKDM4E | |
| SCHEMBL27520204 | 0.82 | NPC1 (0.53) | NHERF1NPC1HPGDMAPTKMT2A | |
| SCHEMBL5679468 | 0.82 | FLT3 (0.51) | SMAD3NHERF1NPC1HPGDKDM4E | |
| SCHEMBL10466165 | 0.82 | MAOA (0.71) | NHERF1NPC1HPGDKDM4EMAPT | |
| SCHEMBL8205569 | 0.81 | MMP13 (0.72) | NPC1HPGDKDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359454-B1 | CC-1065 analogs having two CPI subunits | UPJOHN CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5541339-A | ANTITUMOR AGENTS | THE UPJOHN COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1990002746-A1 | NOVEL CC-1065 ANALOGS HAVING TWO CPI SUBUNITS | THE UPJOHN COMPANY (US) | 1990-03-22 | — | — | WO | disclosed |
| EP-0359454-A1 | Novel CC-1065 analogs having two CPI subunits | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |