Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199051 | 0.88 | MRGPRX4 (0.43) | MRGPRX4GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL8199506 | 0.81 | FNTA (0.50) | — | |
| SCHEMBL8207294 | 0.81 | FNTA (0.50) | — | |
| SCHEMBL8206086 | 0.79 | GAA (0.43) | NR4A2GAASMN1; SMN2TRPM8HTT | |
| SCHEMBL9853966 | 0.74 | TAAR1 (0.61) | NR4A2GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL8205834 | 0.72 | GAA (0.42) | NR4A2GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL5093427 | 0.67 | RAB9A (0.53) | GAASMN1; SMN2HTTKDM4EHTR2B | |
| SCHEMBL8273539 | 0.67 | GAA (0.43) | MRGPRX4GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL28585559 | 0.65 | TAAR1 (0.61) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL28085108 | 0.65 | KDM4E (0.40) | GAASMN1; SMN2KDM4EALDH1A1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |