Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077622 | 0.84 | MAPT (0.56) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL1769996 | 0.84 | MAPT (0.56) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL8207163 | 0.80 | ALDH1A1 (0.46) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL8219508 | 0.79 | LMNA (0.40) | MAPTRAB9ANPC1KMT2AHSD11B1 | |
| SCHEMBL8221266 | 0.79 | RAB9A (0.49) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL8216865 | 0.79 | RAB9A (0.36) | MAPTRAB9ANPC1KMT2ACYP17A1 | |
| SCHEMBL8266779 | 0.78 | MAOB (0.44) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL8215908 | 0.76 | CNR2 (0.36) | MAPTRAB9AKDM4EKMT2AHSD11B1 | |
| SCHEMBL8211974 | 0.76 | GRM1 (0.47) | MAPTKDM4EKMT2AHSD11B1ALDH1A1 | |
| SCHEMBL8268378 | 0.74 | KDM4E (0.48) | MAPTRAB9AKDM4ENPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |