Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | FOS | P01100 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505977 | 0.85 | MAOB (0.53) | MAOBFOSJUNBCHECYP1A2 | |
| SCHEMBL8214695 | 0.82 | ALDH1A1 (0.40) | LMNAMAPTSMN1; SMN2HPGDNPC1 | |
| SCHEMBL8219294 | 0.81 | HPGDS (0.41) | SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL8219508 | 0.79 | LMNA (0.40) | LMNAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8213285 | 0.78 | MAPT (0.45) | JUNCYP1A2CYP1A1CYP1B1MAPT | |
| SCHEMBL8266980 | 0.78 | MEN1 (0.39) | CYP1A2CYP2D6CYP1A1CYP1B1ABCG2 | |
| SCHEMBL8268378 | 0.76 | KDM4E (0.48) | MAOBTRPM8LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8215908 | 0.76 | CNR2 (0.36) | CYP1A2CYP2D6TRPM8LMNAMAPT | |
| SCHEMBL8213322 | 0.75 | PDGFRB (0.42) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8216865 | 0.74 | RAB9A (0.36) | CYP1A2CYP2D6CYP1A1CYP1B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006037996-A1 | NOVEL CYCLIC AND ACYCLIC PROPENONES FOR TREATING CNS DISORDERS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2006-04-13 | — | — | WO | disclosed |