Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536764 | 0.88 | LMNA (0.44) | KMT2APTGER4LMNATSHRRAB9A | |
| SCHEMBL21530644 | 0.87 | TSHR (0.46) | KMT2APTGER4LMNATSHRRAB9A | |
| SCHEMBL28896378 | 0.84 | ALDH1A1 (0.40) | KMT2APTGER4LMNATSHRRAB9A | |
| SCHEMBL28896250 | 0.83 | PTGER4 (0.38) | KMT2APTGER4LMNARAB9AGAA | |
| SCHEMBL4256633 | 0.82 | RAB9A (0.46) | KMT2ALMNARAB9AGAAHTT | |
| SCHEMBL1536739 | 0.81 | TSHR (0.45) | KMT2APTGER4LMNATSHRRAB9A | |
| Hydrochloric Acid SCHEMBL25312311 | 0.80 | TSHR (0.44) | KMT2APTGER4LMNATSHRRAB9A | |
| SCHEMBL28896253 | 0.78 | NUDT1 (0.38) | KMT2APTGER4LMNATSHRRAB9A | |
| SCHEMBL18557963 | 0.77 | KMT2A (0.43) | KMT2ALMNATSHRRAB9AGAA | |
| SCHEMBL28896547 | 0.75 | CNR2 (0.38) | KMT2APTGER4LMNATSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124640-A1 | Pyrrolo[3,2-D]Pyrimidin-4-One Derivative as Myeloperoxidase Inhibitor | ASTRAZENECA AB (SE) | 2009-05-14 | — | — | US | disclosed |
| WO-2007142577-A1 | PYRROLO[3,2-D]PYRIMIDIN-4-ONE DERIVATIVE AS MYELOPEROXIDASE INHIBITOR | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124640-A1 | Pyrrolo[3,2-D]Pyrimidin-4-One Derivative as Myeloperoxidase Inhibitor | MPO, CAT, GPX1 | KMT2A 2251/4885PTGER4 1600/4885LMNA 3540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.