Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | BBOX1 | O75936 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8695365 | 1.00 | ACHE (0.45) | ACHEENPP2APEX1NPSR1DNM1 | |
| Hydrochloric Acid SCHEMBL324011 | 0.92 | ACHE (0.52) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Hydrochloric Acid SCHEMBL2936558 | 0.88 | ACHE (0.52) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Methacrylic Acid SCHEMBL6561454 | 0.87 | ACHE (0.52) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Hydrochloric Acid SCHEMBL7209013 | 0.85 | ACHE (0.39) | ACHEENPP2BBOX1MAPTBLM | |
| Hydrochloric Acid SCHEMBL9497105 | 0.85 | APEX1 (0.48) | ACHEENPP2APEX1NPSR1DNM1 | |
| Hydrochloric Acid SCHEMBL1703796 | 0.82 | ACHE (0.45) | ACHEENPP2APEX1NPSR1DNM1 | |
| Hydrochloric Acid SCHEMBL6846525 | 0.82 | ACHE (0.39) | ACHEENPP2TBXAS1APOBEC3AAPOBEC3G | |
| Methacrylic Acid SCHEMBL159154 | 0.80 | ACHE (0.48) | ACHEENPP2BBOX1APOBEC3AAPOBEC3G | |
| Ammonia Solution, Strong SCHEMBL27915887 | 0.80 | DNM1 (0.54) | ACHEENPP2APEX1NPSR1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090412-A | H2 -Receptor antagonist and antacid composition | YAMAOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-18 | — | — | US | claimed |
| EP-0867191-A1 | DRUG COMPOSITION | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-09-30 | — | — | EP | claimed |
| US-4758437-A | Composition for long acting nicardipine preparation and process of producing the composition | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-07-19 | — | — | US | claimed |
| US-6090412-A | H2 -Receptor antagonist and antacid composition | YAMAOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-18 | — | — | US | disclosed |
| EP-0867191-A1 | DRUG COMPOSITION | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-09-30 | — | — | EP | disclosed |