Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.52 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 7/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL324011 | 0.94 | ACHE (0.52) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Hydrochloric Acid SCHEMBL2936558 | 0.90 | ACHE (0.52) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Methacrylic Acid SCHEMBL159154 | 0.89 | ACHE (0.48) | ACHEENPP2BBOX1CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL8695365 | 0.87 | ACHE (0.45) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Hydrochloric Acid SCHEMBL8222907 | 0.87 | ACHE (0.45) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Hydrochloric Acid SCHEMBL9497105 | 0.86 | APEX1 (0.48) | ACHEENPP2APEX1NPSR1TBXAS1 | |
| Hydrochloric Acid SCHEMBL1703796 | 0.84 | ACHE (0.45) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Hydrochloric Acid SCHEMBL6550800 | 0.81 | BLM (0.41) | ACHEENPP2APEX1BLMPOLB | |
| Methacrylic Acid SCHEMBL673567 | 0.80 | ACHE (0.45) | ACHEENPP2APEX1NPSR1BBOX1 | |
| Hydrochloric Acid SCHEMBL7209013 | 0.80 | ACHE (0.39) | ACHEENPP2BBOX1BLMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900563-B1 | Production of pharmaceutical formulations containing aescin for treatment of edema and venous disorders | KLINGE CO CHEM PHARM FAB (DE) | 2004-02-11 | — | — | EP | claimed |
| EP-0900563-A1 | Production of pharmaceutical formulations containing aescin for treatment of edema and venous disorders | Klinge Pharma GmbH (DE) | 1999-03-10 | — | — | EP | claimed |
| EP-0900563-B1 | Production of pharmaceutical formulations containing aescin for treatment of edema and venous disorders | KLINGE CO CHEM PHARM FAB (DE) | 2004-02-11 | — | — | EP | disclosed |
| US-6077534-A | ADMINISTERING ESCIN; SOLVENT EXTRACTION OF HORSE CHESTNUT SEEDS; MIXING WITH DEXTRIN; PELLETIZATION, DRYING, SIEVING, COATING | KLINGE PHARMA GMBH (DE) | 2000-06-20 | — | — | US | disclosed |
| EP-0900563-A1 | Production of pharmaceutical formulations containing aescin for treatment of edema and venous disorders | Klinge Pharma GmbH (DE) | 1999-03-10 | — | — | EP | disclosed |