Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21266933 | 0.86 | ALDH1A1 (0.41) | ALDH1A1NPSR1ERN1GPR3KDM4E | |
| SCHEMBL28526096 | 0.84 | ALDH1A1 (0.44) | ALDH1A1NPSR1ERN1L3MBTL1KDM4E | |
| SCHEMBL1220795 | 0.80 | ALDH1A1 (0.40) | ALDH1A1NPSR1ERN1GPR3L3MBTL1 | |
| SCHEMBL3718733 | 0.79 | ALDH1A1 (0.69) | ALDH1A1ERN1L3MBTL1KDM4EGAA | |
| SCHEMBL7088703 | 0.79 | TDP1 (0.50) | ALDH1A1ERN1L3MBTL1MAOAMAOB | |
| SCHEMBL207935 | 0.79 | MAOA (0.52) | ALDH1A1ERN1L3MBTL1MAOAMAOB | |
| SCHEMBL29953626 | 0.79 | ALDH1A1 (0.37) | ALDH1A1NPSR1L3MBTL1KDM4EGAA | |
| SCHEMBL15534680 | 0.79 | APP (0.42) | ALDH1A1ERN1L3MBTL1MAOAMAOB | |
| SCHEMBL96209 | 0.77 | ALDH1A1 (0.66) | ALDH1A1NPSR1ERN1L3MBTL1KDM4E | |
| SCHEMBL29951947 | 0.77 | ALDH1A1 (0.66) | ALDH1A1NPSR1ERN1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335378-A | Monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-11-11 | — | — | CN | claimed |
| EP-3686198-B1 | MU-OPIOID RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF IN FIELD OF MEDICINE | SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO LTD (CN) | 2022-12-14 | — | — | EP | disclosed |
| CN-115403570-A | Mu-opioid receptor agonist, preparation method thereof and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-115335378-A | Monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-109516982-B | Mu-opioid receptor agonist, preparation method thereof and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2022-08-23 | — | — | CN | disclosed |
| US-11072601-B2 | μ-opioid receptor agonist and preparation method therefor and use thereof in field of medicine | SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD. (CN) | 2021-07-27 | — | — | US | disclosed |
| US-20200270230-A1 | µ-OPIOID RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF IN FIELD OF MEDICINE | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2020-08-27 | — | — | US | disclosed |
| EP-3686198-A1 | mu-OPIOID RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF IN FIELD OF MEDICINE | Shanghai Synergy Pharmaceutical Sciences Co., Ltd (CN) | 2020-07-29 | — | — | EP | disclosed |
| WO-2007140934-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072601-B2 | μ-opioid receptor agonist and preparation method therefor and use thereof in field of medicine | OPRM1, OPRD1, OPRK1 | ALDH1A1 2383/4885NPSR1 52/4885ERN1 3679/4885 |
| US-20200270230-A1 | µ-OPIOID RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF IN FIELD OF MEDICINE | OPRM1, OPRD1, OPRK1 | ALDH1A1 2316/4885NPSR1 49/4885ERN1 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.