Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220954 | 0.85 | HTR7 (0.46) | ADRB2ADRB1CD274KDM4E | |
| SCHEMBL11480301 | 0.77 | ADRB2 (0.56) | ABCB1ADRB2CYP2D6ADRB1CYP1A2 | |
| SCHEMBL21793185 | 0.74 | HIF1A (0.59) | HTR1AABCB1HIF1AADRB2CYP2D6 | |
| SCHEMBL10336594 | 0.74 | NR2E1 (0.69) | HTR1AABCB1ADRB2CYP2D6ADRB1 | |
| SCHEMBL14364260 | 0.74 | MCHR1 (0.45) | ADRB2ADRB1CD274KDM4E | |
| SCHEMBL16727482 | 0.73 | ABCB1 (0.70) | ABCB1ADRB2ADRB1 | |
| SCHEMBL8225836 | 0.73 | HTR7 (0.44) | ABCB1ADRB2ADRB1KDM4E | |
| SCHEMBL258823 | 0.73 | HIF1A (0.75) | ABCB1HIF1AADRB2CYP2D6ADRB1 | |
| SCHEMBL29997360 | 0.73 | PDCD1 (0.50) | ADRB2CD274KDM4E | |
| SCHEMBL15677631 | 0.72 | ADRB2 (0.65) | ADRB2CYP2D6ADRB1CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070255065-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2007-11-01 | — | — | US | disclosed |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | HTR2C, HTR1D, HTR1A | HTR1A 3/4885ABCB1 924/4885HIF1A 1581/4885 |
| US-20070255065-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | TBXA2R, HTR2C, NPY1R | HTR1A 7/4885ABCB1 872/4885HIF1A 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.