Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10850497 | 0.80 | SNCA (0.57) | SNCAMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL30811554 | 0.80 | SNCA (0.57) | SNCAMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL29850622 | 0.77 | SNCA (0.86) | SNCAMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL1208152 | 0.77 | SNCA (0.86) | SNCAMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10933322 | 0.77 | LMNA (0.45) | SNCAMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL19032766 | 0.72 | CASP1 (0.64) | SNCAMAPTKDM4ELMNACASP1 | |
| SCHEMBL4301111 | 0.71 | LMNA (0.43) | SNCAMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL14445734 | 0.71 | SNCA (0.42) | SNCAMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL19398391 | 0.71 | SNCA (0.76) | SNCAMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL21752000 | 0.71 | SNCA (1.00) | SNCAMAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9980971-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2018-05-29 | — | — | US | disclosed |
| US-20170273986-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2017-09-28 | — | — | US | disclosed |
| US-20170273986-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2017-09-28 | — | — | US | disclosed |
| US-9675621-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2017-06-13 | — | — | US | disclosed |
| US-9675621-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2017-06-13 | — | — | US | disclosed |
| EP-3121169-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WisTa Laboratories Ltd. (SG) | 2017-01-25 | — | — | EP | disclosed |
| US-20160296531-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2016-10-13 | — | — | US | disclosed |
| US-20160296531-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2016-10-13 | — | — | US | disclosed |
| EP-2457905-B1 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LAB LTD (SG) | 2016-08-17 | — | — | EP | disclosed |
| US-9382220-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2016-07-05 | — | — | US | disclosed |
| US-9382220-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2016-07-05 | — | — | US | disclosed |
| EP-2457904-B1 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LAB LTD (SG) | 2014-11-19 | — | — | EP | disclosed |
| EP-2057136-B1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LAB LTD (SG) | 2013-05-22 | — | — | EP | disclosed |
| US-8440821-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2013-05-14 | — | — | US | disclosed |
| US-8440821-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2013-05-14 | — | — | US | disclosed |
| EP-2457904-A1 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | Wista Laboratories Ltd. (SG) | 2012-05-30 | — | — | EP | disclosed |
| EP-2457905-A1 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | Wista Laboratories Ltd. (SG) | 2012-05-30 | — | — | EP | disclosed |
| US-7956183-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2011-06-07 | — | — | US | disclosed |
| US-20090259040-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2009-10-15 | — | — | US | disclosed |
| WO-2008007074-A2 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170273986-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | SNCA 173/4885MAPT 7/4885KDM4E 1825/4885 |
| US-20090259040-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | PARK7, SNCA, GRN | SNCA 2/4885MAPT 4/4885KDM4E 3439/4885 |
| US-20160296531-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | SNCA 173/4885MAPT 7/4885KDM4E 1825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.