SCHEMBL823211

SCHEMBL823211

Cc1cccc(CCN2C(=O)c3ccc(C(=O)O)c4c(C(=O)NCCc5cccc(C(F)(F)F)c5)ccc(c34)C2=O)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
DDT P30046 1/20 0.42
PDE4A P27815 1/20 0.42
PDE4B Q07343 1/20 0.42
PDE4C Q08493 1/20 0.42
PDE4D Q08499 1/20 0.42
GAA P10253 1/20 0.42
RAB9A P51151 3/20 0.41
MAPT P10636 2/20 0.41
POLB P06746 2/20 0.41
ALDH1A1 P00352 2/20 0.41
NPC1 O15118 2/20 0.41
TAAR1 Q96RJ0 1/20 0.41
TP53 P04637 2/20 0.40
RXFP1 Q9HBX9 1/20 0.40
ROCK2 O75116 1/20 0.40
ROCK1 Q13464 1/20 0.40
NLRP3 Q96P20 1/20 0.40
KDM4E B2RXH2 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL823209 0.92 MEN1 (0.49) MEN1KMT2AGAARAB9AMAPT
SCHEMBL12104731 0.88 NPC1 (0.47) MEN1KMT2ADDTPDE4APDE4B
SCHEMBL12175652 0.82 PDE4A (0.40) MEN1KMT2APDE4APDE4BPDE4C
SCHEMBL12104600 0.80 THRB (0.47) MEN1KMT2AGAARAB9AMAPT
SCHEMBL823207 0.80 THRB (0.49) MEN1KMT2AGAARAB9AMAPT
SCHEMBL16352054 0.79 NPC1 (0.59) MEN1KMT2ARAB9AMAPTPOLB
SCHEMBL823199 0.79 NPC1 (0.59) MEN1KMT2ARAB9AMAPTPOLB
SCHEMBL2212466 0.79 NPC1 (0.59) MEN1KMT2ARAB9AMAPTPOLB
SCHEMBL822452 0.78 MEN1 (0.45) MEN1KMT2AGAARAB9AMAPT
SCHEMBL12039531 0.77 POLB (0.49) MEN1KMT2AGAARAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8411489-B2 Semiconducting devices and methods of preparing EASTMAN KODAK COMPANY (US) 2013-04-02 US disclosed
US-8314265-B2 Aromatic amic acids or amic esters and compositions EASTMAN KODAK COMPANY (US) 2012-11-20 US disclosed
US-20110269967-A1 AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS BANK OF AMERICA, N.A., AS AGENT 2011-11-03 US disclosed
WO-2011137139-A1 AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS EASTMAN KODAK COMPANY (US) 2011-11-03 WO disclosed
WO-2011137137-A1 SEMICONDUCTING ARTICLES EASTMAN KODAK COMPANY (US) 2011-11-03 WO disclosed
WO-2011137133-A2 SEMICONDUCTING DEVICES AND METHODS OF PREPARING EASTMAN KODAK COMPANY (US) 2011-11-03 WO disclosed
US-20110266523-A1 SEMICONDUCTING DEVICES AND METHODS OF PREPARING BANK OF AMERICA, N.A., AS AGENT 2011-11-03 US disclosed
US-20110269966-A1 SEMICONDUCTING ARTICLES CITICORP NORTH AMERICA, INC., AS AGENT 2011-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269966-A1 SEMICONDUCTING ARTICLES ALAD, PORCN, DDC MEN1 3245/4885KMT2A 2050/4885DDT 88/4885
US-20110269967-A1 AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS DDC, AADAC, MYOC MEN1 1371/4885KMT2A 1249/4885DDT 315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.