Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.72 |
| ▸ | HLCS | P50747 | 2/20 | 0.70 |
| ▸ | CNR1 | P21554 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | IDE | P14735 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | CNR2 | P34972 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | CA9 | Q16790 | 2/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17704089 | 1.00 | TDP1 (0.72) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL6941477 | 1.00 | TDP1 (0.72) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL13045403 | 0.99 | HLCS (0.71) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL15870672 | 0.99 | HLCS (0.71) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL22493325 | 0.99 | HLCS (0.71) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL12320610 | 0.99 | HLCS (0.71) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL7376597 | 0.99 | HLCS (0.71) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL12729936 | 0.99 | HLCS (0.71) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL13621820 | 0.97 | TDP1 (0.70) | TDP1HLCSCNR1MEN1ABL1 | |
| SCHEMBL14600797 | 0.97 | TDP1 (0.70) | TDP1HLCSCNR1MEN1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129767-A1 | USE OF A GHRELIN AGONIST TO IMPROVE THE CATABOLIC EFFECTS OF GLUCOCORTICOID TREATMENT | BIOMEASURE, INCORPORATED | 2012-05-24 | — | — | US | disclosed |
| US-20110166069-A1 | COMPOSITIONS AND METHODS FOR STIMULATING GASTROINTESTINAL MOTILITY | BIOMEASURE, INCORPORATED | 2011-07-07 | — | — | US | disclosed |
| US-20110160133-A1 | METHOD FOR INHIBITING INFLAMMATION AND PRE-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE | IPSEN PHARMA S.A.S. (FR) | 2011-06-30 | — | — | US | disclosed |
| US-20100227806-A1 | Use Of A Ghrelin Agonist To Improve Catabolic Effects Of Glucocorticoid Treatment | BIOMEASURE, INCORPORATED | 2010-09-09 | — | — | US | disclosed |
| US-20090163416-A1 | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment | IPSEN PHARMA S.A.S. (FR) | 2009-06-25 | — | — | US | disclosed |
| WO-2009020643-A2 | METHOD FOR INHIBITING INFLAMMATION AND PRE-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE | IPSEN PHARMA S.A.S. (FR) | 2009-02-12 | — | — | WO | disclosed |
| WO-2007041278-A2 | COMPOSITION AND METHODS FOR STIMULATING GASTROINTESTINAL MOTILITY | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. (FR) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227806-A1 | Use Of A Ghrelin Agonist To Improve Catabolic Effects Of Glucocorticoid Treatment | GHSR, GHRHR, NR3C1 | TDP1 4739/4885HLCS 3793/4885CNR1 1340/4885 |
| US-20090163416-A1 | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment | GHSR, GHRHR, NR3C1 | TDP1 4219/4885HLCS 4091/4885CNR1 1656/4885 |
| US-20110160133-A1 | METHOD FOR INHIBITING INFLAMMATION AND PRE-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE | PROKR1, PROKR2, CCL2 | TDP1 4705/4885HLCS 2627/4885CNR1 820/4885 |
| US-20110166069-A1 | COMPOSITIONS AND METHODS FOR STIMULATING GASTROINTESTINAL MOTILITY | GIPR, VIP, GRPR | TDP1 4078/4885HLCS 1488/4885CNR1 1858/4885 |
| US-20120129767-A1 | USE OF A GHRELIN AGONIST TO IMPROVE THE CATABOLIC EFFECTS OF GLUCOCORTICOID TREATMENT | GHSR, GHRHR, NR3C1 | TDP1 4292/4885HLCS 4070/4885CNR1 1705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.