Sugi Predict

Sugi Predict / Compounds / SCHEMBL825189

SCHEMBL825189

SCHEMBL825189

c1ccc(CNCCN(Cc2ccccn2)Cc2ccccn2)nc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.68
▸ MAPT P10636 1/20 0.68
▸ LIN28A Q9H9Z2 1/20 0.68
▸ TDP1 Q9NUW8 1/20 0.68
▸ CHRM2 P08172 1/20 0.60
▸ SIRT2 Q8IXJ6 1/20 0.49
▸ KDM4E B2RXH2 2/20 0.48
▸ ALOX15 P16050 2/20 0.48
▸ ALDH1A1 P00352 2/20 0.48
▸ SCN8A Q9UQD0 1/20 0.48
▸ TSHR P16473 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ MAOA P21397 1/20 0.46
▸ MAOB P27338 1/20 0.46
▸ MEN1 O00255 4/20 0.44
▸ KMT2A Q03164 4/20 0.44
▸ CYP1A2 P05177 1/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ HRH3 Q9Y5N1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18301491 0.91 CHRM2 (0.66) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL29386417 0.91 CHRM2 (0.66) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL4274463 0.90 CHRM2 (0.66) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL10607691 0.90 CHRM2 (0.64) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL5362066 0.90 SMN1; SMN2 (0.54) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL4409089 0.87 CHRM2 (0.57) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL19211537 0.86 TDP1 (0.58) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL4515742 0.86 CHRM2 (0.55) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL18549321 0.84 SMN1; SMN2 (0.49) SMN1; SMN2MAPTLIN28ATDP1CHRM2
SCHEMBL6375937 0.84 CHRM2 (0.57) SMN1; SMN2MAPTLIN28ATDP1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260015335-A1 AMINE-SUBSTITUTED FLUORESCENT COMPOUNDS HUGHES HOWARD MED INST (US) 2026-01-15 — — US disclosed
US-20260001857-A1 FLUORINATED FLUORESCENT COMPOUNDS HUGHES HOWARD MED INST (US) 2026-01-01 — — US disclosed
US-20250297958-A1 ZINC-RESPONSIVE FLUOROPHORES NORTHWESTERN UNIVERSITY 2025-09-25 — — US disclosed
US-20250282744-A1 RED-SHIFTED FLUOROPHORES HOWARD HUGHES MEDICAL INSTITUTE 2025-09-11 — — US disclosed
US-12344594-B2 Red-shifted fluorophores HOWARD HUGHES MEDICAL INSTITUTE (US) 2025-07-01 — — US disclosed
US-20240167952-A1 ZINC-RESPONSIVE FLUROPHORES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-05-23 — — US disclosed
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 — — US disclosed
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 — — US disclosed
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 — — US disclosed
EP-3978488-A1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Universitetet I Oslo (NO) 2022-04-06 — — EP disclosed
WO-2011157673-A1 ACCELERATOR SOLUTION AND PROCESS FOR CURING CURABLE RESINS AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) 2011-12-22 — — WO disclosed
EP-1506277-A1 ENZYMATIC DETERGENT COMPOSITIONS UNILEVER N.V. (NL) 2005-02-16 — — EP disclosed
WO-2003097780-A1 ENZYMATIC DETERGENT COMPOSITIONS UNILEVER N.V. (NL) 2003-11-27 — — WO disclosed
EP-1341893-A1 ENZYMATIC DETERGENT COMPOSITIONS UNILEVER N.V. (NL) 2003-09-10 — — EP disclosed
US-20020198127-A1 Liquid cleaning compositions and their use UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2002-12-26 — — US disclosed
WO-2002048307-A1 ENZYMATIC DETERGENT COMPOSITIONS UNILEVER N.V. (NL) 2002-06-20 — — WO disclosed
US-20020066542-A1 Transition metal complexes with polydentate ligands for enhancing the bleaching and delignifying effect of peroxo compounds DEGUSSA AG (DE) 2002-06-06 — — US disclosed
EP-1199402-A2 Process for delignifying and/or bleaching fibrous material Degussa AG (DE) 2002-04-24 — — EP disclosed
WO-2000060043-A1 COMPOSITION AND METHOD FOR BLEACHING A SUBSTRATE UNILEVER PLC (GB) 2000-10-12 — — WO disclosed
WO-2000027975-A1 DETERGENT BLEACHING COMPOSITION UNILEVER PLC (GB) 2000-05-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250297958-A1 ZINC-RESPONSIVE FLUOROPHORES ZKSCAN2, ZFR, SLC30A6 SMN1; SMN2 4113/4885MAPT 2135/4885LIN28A 953/4885
US-12344594-B2 Red-shifted fluorophores TFEB, DDX21, CDC73 SMN1; SMN2 1661/4885MAPT 456/4885LIN28A 1363/4885
US-20240167952-A1 ZINC-RESPONSIVE FLUROPHORES ZFR, ZKSCAN2, ZNF787 SMN1; SMN2 4739/4885MAPT 2620/4885LIN28A 3413/4885
US-20250282744-A1 RED-SHIFTED FLUOROPHORES TFEB, DDX21, CDC73 SMN1; SMN2 1659/4885MAPT 457/4885LIN28A 1362/4885
US-20260001857-A1 FLUORINATED FLUORESCENT COMPOUNDS MSN, CHN2, EFHD2 SMN1; SMN2 1544/4885MAPT 4796/4885LIN28A 2505/4885
US-20260015335-A1 AMINE-SUBSTITUTED FLUORESCENT COMPOUNDS AOC2, H1-2, CHAT SMN1; SMN2 2233/4885MAPT 4489/4885LIN28A 2437/4885
US-11649222-B2 Compounds SLC30A6, SLC39A11, SLC39A3 SMN1; SMN2 3219/4885MAPT 4706/4885LIN28A 3489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.