SCHEMBL825192

SCHEMBL825192

C=C(C)C(=O)OCc1cc(OC)cc(-n2nc3ccc(C(F)(F)F)cc3n2)c1O

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CSNK1D P48730 5/20 0.36
MAPT P10636 2/20 0.35
XPO1 O14980 2/20 0.35
GSTP1 P09211 2/20 0.33
CACNA1D Q01668 1/20 0.33
PTGS1 P23219 1/20 0.32
MC4R P32245 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
GPR139 Q6DWJ6 1/20 0.31
LMNA P02545 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29565119 1.00 CSNK1D (0.36) CSNK1DMAPTXPO1GSTP1CACNA1D
SCHEMBL1098829 0.89 NPC1 (0.36) MAPTXPO1GSTP1NPC1RAB9A
SCHEMBL1101121 0.88 ALDH1A1 (0.36) CSNK1DMAPTMEN1KMT2ALMNA
SCHEMBL825195 0.88 MAPT (0.32) MAPTGSTP1MEN1KMT2ALMNA
SCHEMBL29823665 0.88 MAPT (0.32) MAPTGSTP1MEN1KMT2ALMNA
SCHEMBL1100680 0.87 NPC1 (0.37) MAPTLMNANPC1RAB9A
SCHEMBL1100484 0.86 NPC1 (0.38) MAPTMEN1KMT2ALMNANPC1
SCHEMBL1100373 0.86 MAPT (0.34) MAPTMEN1KMT2ALMNANPC1
SCHEMBL20961133 0.85 MC4R (0.36) CSNK1DGSTP1CACNA1DPTGS1MC4R
SCHEMBL10020867 0.85 MAPT (0.33) MAPTLMNANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 447 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250223392-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC (CH) 2025-07-10 US claimed
US-20240254269-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2024-08-01 US claimed
US-11926689-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2024-03-12 US claimed
EP-3303415-B1 VISIBLE-LIGHT PHOTOINITIATORS AND USES THEREOF ALCON INC (CH) 2022-12-28 EP claimed
US-20220380509-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2022-12-01 US claimed
US-11453736-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2022-09-27 US claimed
EP-3743270-B1 CAST-MOLDING PROCESS FOR PRODUCING UV-ABSORBING CONTACT LENSES ALCON INC (CH) 2022-06-08 EP claimed
US-11111327-B2 Cast-molding process for producing UV-absorbing contact lenses ALCON INC. (CH) 2021-09-07 US claimed
US-20210009743-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC. (CH) 2021-01-14 US claimed
US-10870722-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2020-12-22 US claimed
US-20150094393-A1 METHOD FOR MAKING UV-ABSORBING OPHTHALMIC LENSES ALCON INC. (CH) 2015-04-02 US claimed
EP-2346840-B1 UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS NOVARTIS AG (CH) 2013-12-25 EP claimed
EP-2564245-A1 INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES Novartis AG (CH) 2013-03-06 EP claimed
US-8262948-B2 Intraocular lenses with combinations of UV absorbers and blue light chromophores NOVARTIS AG (CH) 2012-09-11 US claimed
US-8153703-B2 UV/visible light absorbers for ophthalmic lens materials NOVARTIS AG (CH) 2012-04-10 US claimed
WO-2011137142-A1 INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES NOVARTIS AG (CH) 2011-11-03 WO claimed
US-20110266505-A1 INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES ALCON INC. (CH) 2011-11-03 US claimed
EP-2346840-A1 UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS Alcon, Inc. (CH) 2011-07-27 EP claimed
WO-2010053917-A1 UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS ALCON, INC. (CH) 2010-05-14 WO claimed
US-20100113641-A1 UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS ALCON, INC. (CH) 2010-05-06 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100113641-A1 UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS UACA, CRYZ, CRYAA CSNK1D 4202/4885MAPT 45/4885XPO1 1228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.