Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DHPS | P49366 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8253863 | 0.72 | ALDH1A1 (0.50) | CNR2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL12376651 | 0.70 | BRD4 (0.73) | SMN1; SMN2BRD4CNR2ALDH1A1POLB | |
| SCHEMBL7674546 | 0.70 | POLB (0.67) | CNR2ALDH1A1POLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27634849 | 0.69 | POLB (0.65) | CNR2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL3175227 | 0.67 | L3MBTL1 (0.59) | SMN1; SMN2BRD4ALDH1A1POLBMEN1 | |
| SCHEMBL8253681 | 0.67 | MAPT (0.50) | BRD4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1137261 | 0.65 | NOTUM (0.56) | SMN1; SMN2BRD4CNR2POLBMEN1 | |
| SCHEMBL29354330 | 0.63 | ALDH1A1 (0.67) | SMN1; SMN2CNR2ALDH1A1POLBMEN1 | |
| SCHEMBL28069907 | 0.63 | NOTUM (0.62) | SMN1; SMN2BRD4CNR2ALDH1A1POLB | |
| SCHEMBL12376644 | 0.63 | BRD4 (0.57) | SMN1; SMN2BRD4CNR2KDM4EBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350043-B2 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| WO-2006133242-A2 | AZINONE AND DIAZINONE V3 INHIBITORS FOR DEPRESSION AND STRESS DISORDERS | PHARMACOPEIA, INC. (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | HTR3C, HTR3A, AZI2 | SMN1; SMN2 4163/4885BRD4 713/4885CNR2 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.