Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426846 | 0.91 | MAOB (0.61) | LMNAGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17775464 | 0.83 | ALOX15 (0.59) | MEN1KMT2ASMN1; SMN2NPC1ALOX15 | |
| SCHEMBL1257639 | 0.83 | LMNA (0.63) | LMNAGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL171840 | 0.83 | MEN1 (0.61) | GAAMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL4427417 | 0.83 | PKM (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13916156 | 0.83 | KMT2A (0.54) | LMNAMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL778673 | 0.81 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1303739 | 0.81 | ALDH1A1 (0.68) | LMNAGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14949145 | 0.81 | PTGS2 (0.55) | MEN1KMT2ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL26345903 | 0.81 | LMNA (0.61) | LMNAGAAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365196-B2 | Sulphonamido-substituted bridged bicycloalkyl derivatives | MERCK SHARP & DOHME LTD. (GB) | 2008-04-29 | — | — | US | disclosed |
| US-7365196-B2 | Sulphonamido-substituted bridged bicycloalkyl derivatives | MERCK SHARP & DOHME LTD. (GB) | 2008-04-29 | — | — | US | disclosed |
| WO-2006067224-A2 | SPIRO-BENZODIOXOLE AND SPIRO-BENZODIOXANE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | BIOVITRUM AB (PUBL) (SE) | 2006-06-29 | — | — | WO | disclosed |