Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.62 |
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29904797 | 0.85 | HTR7 (1.00) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL3784036 | 0.79 | ALDH1A1 (0.53) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL8415073 | 0.78 | HTR7 (0.84) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| Hydrochloric Acid SCHEMBL11621730 | 0.76 | HTR7 (0.81) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL22138621 | 0.76 | HTR1B (0.53) | HTR7ALDH1A1KDM4ESMN1; SMN2HTR1B | |
| SCHEMBL9868970 | 0.76 | HTR1B (0.53) | HTR7ALDH1A1KDM4ESMN1; SMN2HTR1B | |
| SCHEMBL11023742 | 0.76 | KDM4E (0.86) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL3893843 | 0.75 | HTR7 (0.62) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL5585586 | 0.75 | HTR7 (0.69) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL11018444 | 0.75 | KDM4E (0.83) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704996-B2 | Compounds and compositions useful as cathepsin S inhibitors | NOVARTIS AG (CH) | 2010-04-27 | — | — | US | disclosed |
| US-20090048230-A1 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS | NOVARTIS AG (CH) | 2009-02-19 | — | — | US | disclosed |
| WO-2006018284-A1 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS | NOVARTIS AG (CH) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048230-A1 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS | CTSS, CTSZ, CTSF | HTR7 3898/4885ALDH1A1 4107/4885KDM4E 3038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.