Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273768 | 0.91 | HPGDS (0.38) | ADAM17HPGDSNAMPTPDGFRBKDR | |
| SCHEMBL8217550 | 0.82 | ADAM17 (0.44) | ADAM17HPGDSNAMPT | |
| SCHEMBL8274740 | 0.79 | HPGDS (0.36) | HPGDSKDM4EDPP8DPP9NPC1 | |
| SCHEMBL8274407 | 0.76 | ADAM17 (0.43) | ADAM17NAMPTDPP8DPP9ALDH1A1 | |
| SCHEMBL8276118 | 0.76 | ADAM17 (0.43) | ADAM17NAMPTDPP8DPP9ALDH1A1 | |
| SCHEMBL8275874 | 0.76 | ADAM17 (0.43) | ADAM17NAMPTKDM4EDPP8DPP9 | |
| SCHEMBL8275285 | 0.76 | NAMPT (0.42) | NAMPTHDAC1HDAC2 | |
| SCHEMBL8275791 | 0.75 | KDM4E (0.34) | ADAM17KDM4ENPC1MAPTRAB9A | |
| SCHEMBL8276983 | 0.75 | ADAM17 (0.45) | ADAM17NAMPT | |
| SCHEMBL8275981 | 0.75 | NAMPT (0.42) | ADAM17NAMPTDPP8DPP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |