Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18388882 | 0.77 | ALDH1A1 (0.39) | CYP3A4KDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL2268770 | 0.77 | CYP3A4 (0.56) | CYP3A4SMN1; SMN2ALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL13090795 | 0.75 | MEN1 (0.43) | CYP3A4KDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL19821774 | 0.75 | ALDH1A1 (0.36) | CYP3A4KDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL10068285 | 0.75 | MAPT (0.40) | CYP3A4KDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL23339899 | 0.75 | CYP2D6 (0.39) | CYP3A4KDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL9750702 | 0.74 | IDO1 (0.42) | KDM4ESMN1; SMN2NPSR1ALDH1A1CYP1A2 | |
| SCHEMBL7842347 | 0.73 | CYP2D6 (0.39) | CYP3A4KDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL13949626 | 0.73 | KDM4E (0.63) | KDM4ESMN1; SMN2NPSR1ALDH1A1ALOX15 | |
| SCHEMBL8948290 | 0.72 | LMNA (0.51) | KDM4ESMN1; SMN2ALDH1A1HPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129818-A1 | Compositions and Methods for Treatment of Cardiovascular Disease | CARMEL BIOSCIENCES, INC. | 2012-05-24 | — | — | US | disclosed |
| US-20120129818-A1 | Compositions and Methods for Treatment of Cardiovascular Disease | CARMEL BIOSCIENCES, INC. | 2012-05-24 | — | — | US | disclosed |
| WO-2010124201-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF CARDIOVASCULAR DISEASE | INVASC THERAPEUTICS, INC. (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129818-A1 | Compositions and Methods for Treatment of Cardiovascular Disease | APOB, LDLR, APOL1 | CYP3A4 1628/4885KDM4E 969/4885SMN1; SMN2 2146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.