Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285359 | 0.89 | KDM4E (0.47) | GAAADORA3MAPTKDM4ERAB9A | |
| SCHEMBL8287944 | 0.87 | GAA (0.43) | GAAMAPTKDM4ERAB9AHTT | |
| SCHEMBL8287996 | 0.84 | MAPT (0.43) | GAAPOLBMAPTKDM4ERAB9A | |
| SCHEMBL8358804 | 0.84 | MAT2A (0.41) | GAAMAPTKDM4EHTTSMN1; SMN2 | |
| SCHEMBL8287217 | 0.83 | RIPK1 (0.43) | MAPTKDM4ERAB9AHTTSMN1; SMN2 | |
| SCHEMBL8286535 | 0.83 | OPRK1 (0.45) | GAAADORA3ADORA1MAPTSMN1; SMN2 | |
| SCHEMBL5871645 | 0.82 | GAA (0.42) | GAAMAPTKDM4ERAB9AHTT | |
| SCHEMBL8286452 | 0.82 | PDE11A (0.44) | GAAPOLBMAPTKDM4EKDR | |
| SCHEMBL8286573 | 0.82 | GAA (0.42) | GAAPOLBMAPTKDM4ERAB9A | |
| SCHEMBL5872108 | 0.81 | GAA (0.44) | GAAMAPTKDM4ERAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |