Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358804 | 0.91 | MAT2A (0.41) | OPRK1TSHRKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL5871913 | 0.87 | ALDH1A1 (0.42) | OPRK1TSHRADORA1GAAMAPK1 | |
| SCHEMBL8285359 | 0.86 | KDM4E (0.47) | TSHRKCNJ6KCNJ5KCNJ3ADORA3 | |
| SCHEMBL8287944 | 0.84 | GAA (0.43) | TSHRGAAMAPK1HPGDSMN1; SMN2 | |
| SCHEMBL8285272 | 0.84 | PDE11A (0.37) | OPRK1TSHRGAAMAPK1HPGD | |
| SCHEMBL8285358 | 0.83 | GAA (0.43) | ADORA3ADORA1GAAHPGDSMN1; SMN2 | |
| SCHEMBL8286558 | 0.83 | PDE11A (0.46) | TSHRGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL8287405 | 0.83 | OPRK1 (0.53) | OPRK1TSHRKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8287533 | 0.83 | SLC2A1 (0.44) | OPRK1GAAMAPK1HPGDSLC2A1 | |
| SCHEMBL8286548 | 0.82 | SMN1; SMN2 (0.50) | TSHRGAAMAPK1SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |