Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362929 | 0.85 | PIK3CA (0.44) | HCAR3GSK3BPIK3CAPRKDCCDK4 | |
| SCHEMBL8362927 | 0.85 | MAT2A (0.44) | RAB9AGSK3BEGFRKDM4EALDH1A1 | |
| SCHEMBL8287514 | 0.84 | EGFR (0.42) | RAB9AHCAR3GSK3BPIK3CAPRKDC | |
| SCHEMBL8287483 | 0.84 | ADORA3 (0.45) | RAB9AEGFRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8286470 | 0.82 | KCNH3 (0.40) | HCAR3GSK3BPIK3CAPRKDCCDK4 | |
| SCHEMBL8287208 | 0.81 | ALDH1A1 (0.41) | RAB9APIK3CAPRKDCEGFRKDM4E | |
| SCHEMBL8287481 | 0.80 | MAT2A (0.49) | GSK3BPIK3CAPRKDCEGFRKDM4E | |
| SCHEMBL8285319 | 0.80 | PIK3CA (0.43) | RAB9AGSK3BPIK3CAPRKDCNPC1 | |
| SCHEMBL8285309 | 0.80 | BTK (0.43) | GSK3BPIK3CAPRKDCCDK4BTK | |
| SCHEMBL8287230 | 0.79 | PIK3CA (0.41) | HCAR3GSK3BPIK3CAPRKDCCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |