Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300657 | 0.91 | PTPN5 (0.47) | CNR1SIRT1SIRT2SNCAMEN1 | |
| SCHEMBL27398702 | 0.81 | PLA2G2A (0.48) | ADRA2AADRA2BADRA2CHTR7HTR2B | |
| SCHEMBL8295618 | 0.78 | HTR1A (0.47) | HTR7HTR6CNR1SIRT1SIRT2 | |
| SCHEMBL1757962 | 0.75 | KDM4E (0.73) | ADRA2AADRA2BADRA2CHTR7HTR2B | |
| SCHEMBL8296306 | 0.73 | PRSS1 (0.55) | ADRA2AADRA2BADRA2CHTR7HTR2B | |
| SCHEMBL1757929 | 0.72 | AKR1C2 (0.54) | ADRA2AADRA2BADRA2CHTR7HTR2B | |
| SCHEMBL17829970 | 0.71 | HTR6 (0.75) | ADRA2AADRA2BADRA2CHTR7HTR2B | |
| SCHEMBL7964644 | 0.70 | SLC2A1 (0.44) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL27644764 | 0.70 | MEN1 (0.59) | ADRA2AADRA2BADRA2CHTR7HTR2B | |
| SCHEMBL1757128 | 0.70 | POLB (0.54) | ADRA2AADRA2BADRA2CHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |