Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293138 | 0.91 | ADRA2A (0.47) | KDM4EALDH1A1SNCAGAAMAPT | |
| SCHEMBL27398702 | 0.83 | PLA2G2A (0.48) | PTPN5KDM4EALDH1A1THRBPLA2G2A | |
| SCHEMBL13401405 | 0.74 | KDM4E (0.73) | PTPN5KDM4EALDH1A1THRBHPGD | |
| SCHEMBL8295618 | 0.74 | HTR1A (0.47) | PLA2G2AMEN1KMT2ASIRT2SIRT1 | |
| SCHEMBL25811506 | 0.70 | KDM4E (0.67) | PTPN5KDM4EALDH1A1THRBHPGD | |
| SCHEMBL5881620 | 0.70 | PTPN5 (0.57) | PTPN5KDM4EALDH1A1THRBHPGD | |
| SCHEMBL8529584 | 0.70 | PTPN5 (0.62) | PTPN5KDM4EALDH1A1THRBHPGD | |
| SCHEMBL1757962 | 0.69 | KDM4E (0.73) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL5881790 | 0.69 | PTPN5 (0.58) | PTPN5KDM4EALDH1A1THRBHPGD | |
| SCHEMBL20957066 | 0.68 | TAS2R14 (0.51) | KDM4EALDH1A1HPGDRECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |