Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 5/20 | 0.48 |
| ▸ | RARB | P10826 | 5/20 | 0.48 |
| ▸ | RXRA | P19793 | 8/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | RXRB | P28702 | 4/20 | 0.32 |
| ▸ | RXRG | P48443 | 3/20 | 0.32 |
| ▸ | RARG | P13631 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708359 | 0.86 | RARA (0.44) | RARARARBRXRAHNF4APTGS1 | |
| SCHEMBL12715251 | 0.83 | RARA (0.43) | RARARARBRXRAHNF4ARARG | |
| SCHEMBL8700476 | 0.81 | RARB (0.58) | RARARARBRXRAHNF4APPARG | |
| SCHEMBL8293242 | 0.78 | RARA (0.48) | RARARARBHNF4APTGS1PTGS2 | |
| SCHEMBL5023386 | 0.78 | RARA (0.41) | RARARARBHNF4ARARGMEN1 | |
| SCHEMBL17675356 | 0.73 | RARB (0.44) | RARARARBHNF4ARARGMEN1 | |
| SCHEMBL9143502 | 0.73 | GABRA1 (0.38) | RARARARBHNF4APTGS1PTGS2 | |
| SCHEMBL2978073 | 0.73 | RARA (0.38) | RARARARBHNF4ARARGL3MBTL1 | |
| SCHEMBL8699677 | 0.73 | RARA (0.44) | RARARARBRARGKMT2A | |
| SCHEMBL12107981 | 0.73 | HTR2C (0.36) | RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923579-B2 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods | EXONHIT THERAPEUTICS S.A. (FR) | 2011-04-12 | — | — | US | disclosed |
| EP-1692097-B1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2009-09-02 | — | — | EP | disclosed |
| US-20070129368-A1 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods | EXONHIT THERAPEUTICS S.A. (FR) | 2007-06-07 | — | — | US | disclosed |
| WO-2005058803-A1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129368-A1 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods | HDAC5, HDAC1, HDAC2 | RARA 1012/4885RARB 998/4885RXRA 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.