Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304879 | 0.97 | KDM4E (0.42) | KDM4EMEN1ALDH1A1KMT2ATRPV6 | |
| SCHEMBL8300030 | 0.93 | KDM4E (0.45) | KDM4EMEN1ALDH1A1KMT2ATRPV6 | |
| SCHEMBL8300679 | 0.88 | CCR3 (0.39) | CYP2D6ITGB3ITGA2B | |
| SCHEMBL8304380 | 0.85 | DRD3 (0.36) | KDM4EMEN1ALDH1A1KMT2ATRPV6 | |
| SCHEMBL8300686 | 0.85 | NAMPT (0.43) | KDM4EMEN1ALDH1A1KMT2ATRPV6 | |
| SCHEMBL8300003 | 0.84 | CCR3 (0.39) | CYP2D6ITGB3ITGA2B | |
| SCHEMBL8298652 | 0.83 | ITGB3 (0.45) | KDM4EMEN1ALDH1A1KMT2ATRPV6 | |
| SCHEMBL8299936 | 0.82 | KDM4E (0.41) | KDM4EMEN1ALDH1A1KMT2ATRPV6 | |
| SCHEMBL8318264 | 0.82 | DRD2 (0.47) | TRPV6ITGB3ITGA2B | |
| SCHEMBL8305139 | 0.82 | CDK9 (0.36) | KDM4EMEN1ALDH1A1KMT2ATRPV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808306-B1 | NEW DERIVATIVES OF PYRIDINE OR PYRIDAZINE, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-04 | — | — | EP | disclosed |