SCHEMBL8302527

SCHEMBL8302527

CCCCCCCCC1CCc2cc(-c3ccc(O)cc3)nc(F)c2C1=O

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.34
MAPT P10636 1/20 0.34
STAT3 P40763 1/20 0.34
RAB9A P51151 1/20 0.34
ATM Q13315 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP26A1 O43174 4/20 0.34
GRM2 Q14416 1/20 0.34
CYP19A1 P11511 4/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
ESR2 Q92731 2/20 0.33
ESRRB O95718 1/20 0.33
ESR1 P03372 1/20 0.33
ESRRA P11474 1/20 0.33
CYP24A1 Q07973 1/20 0.32
PPARG P37231 1/20 0.32
XDH P47989 2/20 0.32
DRD2 P14416 1/20 0.32
DRD1 P21728 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8298256 0.87 THRA (0.46) NPC1MAPTRAB9ACYP19A1THRA
SCHEMBL8437511 0.80 CYP26A1 (0.36) CYP26A1CYP19A1ESR2ESRRBESR1
SCHEMBL8305007 0.77 CYP3A4 (0.39) NPC1MAPTSTAT3RAB9AATM
SCHEMBL8296050 0.76 NPC1 (0.34) NPC1MAPTSTAT3RAB9AATM
SCHEMBL8301428 0.68 THRA (0.34) THRATHRB
SCHEMBL8034977 0.67 CYP19A1 (0.57) CYP26A1CYP19A1THRATHRBESR2
SCHEMBL8305593 0.65 XDH (0.40) NPC1MAPTRAB9ASMN1; SMN2CYP19A1
SCHEMBL8298273 0.64 GPR84 (0.34) THRATHRBPPARG
SCHEMBL27919093 0.64 CYP19A1 (0.56) MAPTSMN1; SMN2CYP19A1THRATHRB
SCHEMBL14033511 0.63 HSP90AA1 (0.48) NPC1MAPTRAB9ASMN1; SMN2THRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824521-B1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES AVENTIS RES & TECH GMBH & CO (DE) 1999-12-01 EP disclosed
US-5874023-A ELECTROOPTICS, DISPLAYS HOECHST AKTIENGESELLSCHAFT (DE) 1999-02-23 US disclosed
EP-0824521-A1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-25 EP disclosed
WO-1996035673-A1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-14 WO disclosed