Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296764 | 0.88 | HTR2A (0.52) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8302784 | 0.84 | HTR7 (0.56) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8297500 | 0.83 | HTR1A (0.53) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8303699 | 0.79 | ADRA1D (0.57) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8296717 | 0.79 | HTR1A (0.56) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8303139 | 0.79 | DRD2 (0.48) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8303547 | 0.78 | DRD2 (0.51) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8298653 | 0.75 | DRD2 (0.52) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8299874 | 0.73 | OPRM1 (0.50) | DRD2HTR7HTR2AKCNH2SLC6A4 | |
| SCHEMBL8298191 | 0.73 | HTR1A (0.56) | HTR7HTR2AHTR1BADRA1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |