Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303556 | 0.97 | SIGMAR1 (0.43) | SIGMAR1CCR3OPRM1OPRD1OPRK1 | |
| SCHEMBL8303871 | 0.94 | OPRM1 (0.42) | SIGMAR1CCR3OPRM1OPRD1OPRK1 | |
| SCHEMBL8303444 | 0.89 | SIGMAR1 (0.55) | SIGMAR1POLBCCR3DRD2HTR2B | |
| SCHEMBL8306497 | 0.87 | SIGMAR1 (0.42) | SIGMAR1CCR3OPRM1OPRD1OPRK1 | |
| SCHEMBL8304636 | 0.80 | OPRM1 (0.41) | POLBCCR3OPRM1OPRD1OPRK1 | |
| SCHEMBL9175467 | 0.77 | SIGMAR1 (0.40) | SIGMAR1CCR3 | |
| SCHEMBL9143193 | 0.76 | DRD2 (0.39) | CCR3DRD2 | |
| SCHEMBL8412493 | 0.75 | SIGMAR1 (0.40) | SIGMAR1POLB | |
| SCHEMBL9176466 | 0.75 | SLC6A2 (0.37) | SIGMAR1CCR3 | |
| SCHEMBL8121244 | 0.75 | HTR7 (0.58) | OPRM1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | claimed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | claimed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | claimed |
| JP-6179670-A | — | — | None | — | — | JP | disclosed |
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| JP-H06179670-A | NOVEL 1,4-DISUBSTITUTED PIPERADINES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION | ADIR | 1994-06-28 | — | — | JP | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |