Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303201 | 0.97 | SIGMAR1 (0.43) | SIGMAR1CCR3DRD2HTR2BOPRM1 | |
| SCHEMBL8303871 | 0.93 | OPRM1 (0.42) | SIGMAR1CCR3DRD2OPRM1OPRD1 | |
| SCHEMBL8306497 | 0.86 | SIGMAR1 (0.42) | SIGMAR1CCR3KMT2AOPRM1OPRD1 | |
| SCHEMBL8303444 | 0.86 | SIGMAR1 (0.55) | SIGMAR1CCR3MEN1TP53CYP1A2 | |
| SCHEMBL8304636 | 0.79 | OPRM1 (0.41) | CCR3DRD2OPRM1OPRD1OPRK1 | |
| SCHEMBL8121244 | 0.76 | HTR7 (0.58) | MEN1CYP1A2CYP3A4CYP2D6KMT2A | |
| SCHEMBL9175467 | 0.76 | SIGMAR1 (0.40) | SIGMAR1CCR3 | |
| SCHEMBL9179831 | 0.76 | SIGMAR1 (0.38) | SIGMAR1CCR3MEN1TP53CYP1A2 | |
| SCHEMBL9143193 | 0.75 | DRD2 (0.39) | CCR3DRD2 | |
| SCHEMBL9176466 | 0.74 | SLC6A2 (0.37) | SIGMAR1CCR3MEN1TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |