SCHEMBL8303382

SCHEMBL8303382

Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(CO)c(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B2 P37059 1/20 0.34
NR1H2 P55055 7/20 0.33
NR1H3 Q13133 7/20 0.33
AKR1B1 P15121 1/20 0.32
LMNA P02545 1/20 0.32
NR1I2 O75469 1/20 0.32
NR3C1 P04150 1/20 0.32
AR P10275 1/20 0.32
RXRA P19793 1/20 0.32
RORC P51449 1/20 0.32
KDM4E B2RXH2 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PTGES O14684 1/20 0.31
MAPK14 Q16539 1/20 0.31
PDE2A O00408 1/20 0.31
PDE10A Q9Y233 1/20 0.31
SCN9A Q15858 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8298161 0.85 HSD17B2 (0.39) HSD17B2NR1H2NR1H3AKR1B1LMNA
SCHEMBL8300515 0.83 GABRA5 (0.34) RXRAKDM4ENPSR1PTGES
SCHEMBL8298151 0.83 MRGPRX4 (0.38) LMNAKDM4ENPSR1SMN1; SMN2SCN9A
SCHEMBL9251182 0.79 MAPT (0.38) HSD17B2NR1H2NR1H3LMNAKDM4E
SCHEMBL8880240 0.78 L3MBTL1 (0.33) RORCKDM4ENPSR1PTGES
SCHEMBL8300795 0.78 NR1H2 (0.40) HSD17B2NR1H2NR1H3AKR1B1LMNA
SCHEMBL8942539 0.78 NR1H2 (0.44) HSD17B2NR1H2NR1H3LMNAKDM4E
SCHEMBL8300261 0.77 NR1H2 (0.39) HSD17B2NR1H2NR1H3AKR1B1LMNA
SCHEMBL8875393 0.76 HSD11B1 (0.36) NR1H2NR1H3KDM4ENPSR1PTGES
SCHEMBL8303453 0.76 HSD17B2 (0.44) HSD17B2NR1H2NR1H3LMNAPTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1058963-C Triazole derivative, insecticidal/acaricidal agent, and process for producing the same KUMIAI CHEMICAL INDUSTRY CO (JP) 2000-11-29 CN disclosed
EP-0648752-B1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-10-06 EP disclosed
US-5700824-A Triazole derivatives, insecticide, acaricide and methods thereof KUMIAI CHEMICAL INDUSTRIAL CO. LTD. (JP) 1997-12-23 US disclosed
US-5616594-A Triazole derivatives, insecticide, acaricide and methods thereof IHARA CHEMICAL INDUSTRY CO. LTD. (JP) 1997-04-01 US disclosed
CN-1105179-A Triazole derivative, insecticidal/acaricidal agent, and process for producing the same KUMIAI CHEMICAL INDUSTRY CO (JP) 1995-07-12 CN disclosed
EP-0648752-A1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-19 EP disclosed