Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 4/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509566 | 0.75 | LMNA (0.81) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL3078492 | 0.74 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL188019 | 0.74 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL41890 | 0.74 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL678045 | 0.74 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL9213198 | 0.74 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL15146 | 0.74 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| SCHEMBL10385161 | 0.73 | CHRM5 (0.58) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL7076217 | 0.73 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA | |
| Pilocarpine SCHEMBL725541 | 0.73 | LMNA (1.00) | CHRM5CHRM4CHRM1CHRM3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486806-B1 | Process for the preparation of racemic pilosinine derivatives | MERCK PATENT GMBH (DE) | 1996-01-17 | — | — | EP | claimed |
| JP-5059044-A | — | — | None | — | — | JP | disclosed |
| JP-5059044-A | — | — | None | — | — | JP | disclosed |
| EP-4644366-A1 | PREPARATION METHODS FOR PILOCARPINE AND INTERMEDIATE COMPOUND THEREOF | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2025-11-05 | — | — | EP | disclosed |
| CN-116199607-B | Preparation method of pilocarpine and intermediate compound thereof | 浙江奥翔药业股份有限公司 | 2025-02-14 | — | — | CN | disclosed |
| US-20240228425-A1 | PREPARATION METHOD OF PILOCARPINE AND ITS INTERMEDIATE COMPOUNDS | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2024-07-11 | — | — | US | disclosed |
| WO-2024140282-A1 | PREPARATION METHODS FOR PILOCARPINE AND INTERMEDIATE COMPOUND THEREOF | 浙江奥翔药业股份有限公司 | 2024-07-04 | — | — | WO | disclosed |
| WO-2019150341-A1 | COMBINATION OF AN ANTIMUSCARINIC OR AN ANTICHOLINERGIC AGENT AND LIPOIC ACID AND USES THEREOF | CELLIXBIO PRIVATE LIMITED (IN) | 2019-08-08 | — | — | WO | disclosed |
| EP-0647640-B1 | Process for the preparation of pilocarpine derivatives | MERCK PATENT GMBH (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5530136-A | HIGH YIELD; BY-PRODUCT INHIBITION | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-06-25 | — | — | US | disclosed |
| EP-0486806-B1 | Process for the preparation of racemic pilosinine derivatives | MERCK PATENT GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| EP-0647640-A1 | Process for the preparation of pilocarpine derivatives | MERCK PATENT GmbH (DE) | 1995-04-12 | — | — | EP | disclosed |
| JP-H0559044-A | PREPARATION OF RACEMIC PILOSININE DERIVATIVE | MERCK PATENT GMBH | 1993-03-09 | — | — | JP | disclosed |
| JP-H0559044-A | PREPARATION OF RACEMIC PILOSININE DERIVATIVE | MERCK PATENT GMBH | 1993-03-09 | — | — | JP | disclosed |
| US-5180837-A | PILOSININE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-01-19 | — | — | US | disclosed |
| US-5180837-A | PILOSININE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-01-19 | — | — | US | disclosed |
| US-5180837-A | PILOSININE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-01-19 | — | — | US | disclosed |
| EP-0486806-A1 | Process for the preparation of racemic pilosinine derivatives | MERCK PATENT GmbH (DE) | 1992-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228425-A1 | PREPARATION METHOD OF PILOCARPINE AND ITS INTERMEDIATE COMPOUNDS | CYP4B1, CYP4A11, CYP3A4 | CHRM5 534/4885CHRM4 426/4885CHRM1 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.