Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9143190 | 0.83 | DRD2 (0.47) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL8307032 | 0.82 | HRH3 (0.50) | ADRA1DADRA1AADRA1BDRD2HTR7 | |
| SCHEMBL9179337 | 0.81 | DRD2 (0.43) | DRD2HTR1AHTR2A | |
| SCHEMBL8303443 | 0.79 | HTR1A (0.58) | DRD2HTR1A | |
| SCHEMBL8304293 | 0.79 | DRD2 (0.70) | DRD2HTR1A | |
| SCHEMBL8304635 | 0.78 | DRD4 (0.43) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL8303869 | 0.76 | ALDH1A1 (0.40) | DRD2HTR1AHTR2A | |
| SCHEMBL9178359 | 0.76 | DRD2 (0.41) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL8303187 | 0.74 | DRD2 (0.37) | DRD2HTR1AHTR2A | |
| SCHEMBL9175463 | 0.74 | DRD2 (0.42) | DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | claimed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | claimed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | claimed |
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |