Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 7/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784774 | 0.85 | DRD2 (0.55) | DRD2HTR4ACHECHRM4CHRM5 | |
| SCHEMBL7029357 | 0.76 | QDPR (0.52) | DRD2MEN1KMT2AKDM4E | |
| SCHEMBL7938441 | 0.73 | KDM4E (0.46) | KDM4EADRA1A | |
| SCHEMBL6646479 | 0.73 | DRD2 (0.52) | DRD2MEN1KMT2AADRA1DADRA1A | |
| SCHEMBL6815771 | 0.72 | MEN1 (0.45) | MEN1KMT2AKCNH2 | |
| SCHEMBL8304631 | 0.72 | HTR4 (0.36) | DRD2HTR4ACHEMEN1KMT2A | |
| SCHEMBL7880812 | 0.72 | HTR2A (0.47) | — | |
| SCHEMBL6924205 | 0.72 | ABCB1 (0.43) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL14320526 | 0.72 | SIGMAR1 (0.46) | DRD2MEN1KMT2A | |
| SCHEMBL6717514 | 0.71 | EHMT2 (0.42) | DRD2MEN1KMT2AKDM4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |