Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544668 | 0.79 | SMAD3 (0.41) | POLBHTT | |
| SCHEMBL11096785 | 0.77 | TDP1 (0.35) | KDM4EPOLBSMN1; SMN2TDP1HTT | |
| SCHEMBL5035909 | 0.76 | L3MBTL1 (0.35) | POLBSMN1; SMN2TDP1HTTLMNA | |
| SCHEMBL10925744 | 0.74 | POLB (0.34) | KDM4EPOLBSMN1; SMN2TDP1LMNA | |
| SCHEMBL10811492 | 0.74 | MEN1 (0.40) | KDM4EPOLBSMN1; SMN2TDP1HTT | |
| SCHEMBL5041026 | 0.74 | MEN1 (0.37) | KDM4ESMN1; SMN2TDP1HTTLMNA | |
| SCHEMBL19465758 | 0.74 | ALDH1A1 (0.35) | KDM4ETDP1LMNAALDH1A1CHEK2 | |
| SCHEMBL251109 | 0.74 | LMNA (0.53) | KDM4EPOLBSMN1; SMN2TDP1HTT | |
| SCHEMBL4279399 | 0.74 | HPGD (0.51) | KDM4EPOLBSMN1; SMN2HTTLMNA | |
| SCHEMBL11842748 | 0.73 | CHEK2 (0.41) | LMNACHEK2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143421-B2 | Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-03-27 | — | — | US | disclosed |
| EP-1485358-B1 | BROADSPECTRUM SUBSTITUTED BENZIMIDAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS | TIBOTEC PHARM LTD (IE) | 2011-02-02 | — | — | EP | disclosed |
| US-20090203743-A1 | SMALL MOLECULE ENTRY INHIBITORS | SURLERAUX DOMINIQUE LOUIS | 2009-08-13 | — | — | US | disclosed |
| US-20050171175-A1 | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors | TIBOTEC PHARMACEUTICALS LTD (IE) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203743-A1 | SMALL MOLECULE ENTRY INHIBITORS | NR0B1, LTC4S, LTB4R | KDM4E 3667/4885POLB 3410/4885SMN1; SMN2 4490/4885 |
| US-20050171175-A1 | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors | CYP2S1, CYP2C8, PRSS8 | KDM4E 3756/4885POLB 2712/4885SMN1; SMN2 4368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.