Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304050 | 0.88 | HRH2 (0.47) | KMT2AHRH2HRH1MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8306472 | 0.87 | HRH2 (0.46) | KMT2AHRH2HRH1MEN1ALDH1A1 | |
| SCHEMBL8303793 | 0.83 | GAA (0.49) | KMT2AKDM4EMEN1ALDH1A1USP2 | |
| SCHEMBL8303218 | 0.74 | MEN1 (0.39) | KMT2AMEN1ALDH1A1TSHRMAPK1 | |
| SCHEMBL8873628 | 0.74 | L3MBTL1 (0.47) | KMT2AKDM4EMEN1ALDH1A1TSHR | |
| SCHEMBL9235427 | 0.70 | PKM (0.45) | KDM4EHRH2HRH1ALDH1A1TRPV4 | |
| SCHEMBL9520302 | 0.69 | RAB9A (0.45) | TSHRMAPK1SMN1; SMN2THRB | |
| Hydrochloric Acid SCHEMBL9522648 | 0.69 | RAB9A (0.47) | TSHRMAPK1SMN1; SMN2THRB | |
| SCHEMBL6999554 | 0.68 | HRH2 (0.48) | HRH2HRH1ALDH1A1SMN1; SMN2TRPV4 | |
| SCHEMBL9337665 | 0.67 | MLYCD (0.76) | KMT2AKDM4EMEN1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665228-B1 | Pharmaceutical compositions containing 3-phenylsulfonyl-3,7-diazabicyclo 3,3,1 nonanes | SOLVAY PHARM GMBH (DE) | 1999-07-14 | — | — | EP | disclosed |
| US-5635511-A | ACID ADDITION SALT DERIVATIVES; ANTIARRHYTHMIA AGENTS; ACTIVE SUPPRESSION OF EXTRASYSTOLES, VENTRICULAR FLUTTERS AND FIBRILLATIONS | KALI-CHEMIE PHARMA GMBH (DE) | 1997-06-03 | — | — | US | disclosed |
| US-5576327-A | Treatment of heart rhythym disorders by administration of 3-phenylsulfonyl-3, 7-diazabicyclo[3.3.1]nonane compounds | KALI-CHEMIE PHARMA GMBH (DE) | 1996-11-19 | — | — | US | disclosed |
| EP-0665228-A1 | Pharmaceutical compositions containing 3-phenylsulfonyl-3,7-diazabicyclo 3,3,1 nonanes | Kali-Chemie Pharma GmbH (DE) | 1995-08-02 | — | — | EP | disclosed |