Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320549 | 0.81 | HTT (0.59) | LMNAMAPTPOLBPKMKMT2A | |
| SCHEMBL8037879 | 0.81 | POLB (0.61) | LMNAGAAMAPTPOLBPKM | |
| Water SCHEMBL11515624 | 0.80 | HTT (0.58) | LMNAMAPTPOLBPKMKMT2A | |
| SCHEMBL384743 | 0.79 | GAA (0.57) | LMNAGAAMAPTPOLBPKM | |
| SCHEMBL6794454 | 0.79 | LMNA (0.55) | LMNAGAAMAPTPOLBPKM | |
| SCHEMBL9064975 | 0.79 | ALDH1A1 (0.51) | MAPTPOLBKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11489461 | 0.78 | GAA (0.55) | LMNAGAAMAPTPOLBPKM | |
| SCHEMBL10568442 | 0.78 | LMNA (0.59) | LMNAGAAMAPTPOLBPKM | |
| SCHEMBL11531056 | 0.78 | LMNA (0.53) | LMNAGAAMAPTPOLBPKM | |
| SCHEMBL1849340 | 0.78 | LMNA (0.53) | LMNAGAAMAPTPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0914318-A1 | PYRAZINES | KINGS COLLEGE LONDON (GB) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997043267-A1 | PYRAZINES | KINGS COLLEGE LONDON (GB) | 1997-11-20 | — | — | WO | disclosed |