Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6037050 | 0.85 | NOTUM (0.35) | MAPTTHRBMEN1KMT2ANOTUM | |
| SCHEMBL4970985 | 0.72 | ALDH1A1 (0.64) | ALDH1A1MAPTHTTLMNATHRB | |
| SCHEMBL4970993 | 0.72 | ALDH1A1 (0.64) | ALDH1A1MAPTHTTLMNATHRB | |
| SCHEMBL4970673 | 0.68 | ALDH1A1 (0.49) | ALDH1A1MAPTHTTLMNAMEN1 | |
| SCHEMBL4970676 | 0.68 | ALDH1A1 (0.49) | ALDH1A1MAPTHTTLMNAMEN1 | |
| SCHEMBL14433154 | 0.68 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNAPKM | |
| SCHEMBL4970588 | 0.67 | RXRA (0.48) | — | |
| SCHEMBL5276043 | 0.63 | USP30 (0.42) | ALDH1A1MAPTHTTLMNATHRB | |
| SCHEMBL26720935 | 0.61 | RARA (0.52) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25252123 | 0.60 | MAPT (0.49) | ALDH1A1MAPTHTTLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933351-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0933350-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0800504-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020914-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-07-11 | — | — | WO | disclosed |