Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313599 | 0.86 | GBA1 (0.49) | HSD11B1CA12CA1CA2CA9 | |
| SCHEMBL8311501 | 0.82 | LSS (0.55) | HSD11B1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL6978099 | 0.75 | CHRNB2 (0.48) | CHRM4KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL9730560 | 0.74 | GBA1 (0.62) | KDM4EMEN1HPGDALDH1A1MAPT | |
| SCHEMBL6980904 | 0.74 | LSS (0.68) | HPGDALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL6983696 | 0.74 | GBA1 (0.50) | CHRM4KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6978836 | 0.74 | GPR119 (0.57) | CHRM4HPGDKMT2AGBA1 | |
| SCHEMBL6980850 | 0.73 | LSS (0.61) | MEN1KMT2ASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL623587 | 0.72 | L3MBTL1 (0.48) | CHRM4KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8309885 | 0.72 | MEN1 (0.62) | HSD11B1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |