Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313599 | 0.86 | GBA1 (0.49) | CA12CA1CA2CA9HSD11B1 | |
| SCHEMBL8289982 | 0.85 | LSS (0.65) | LSSKMT2AMEN1HPGDMAPT | |
| SCHEMBL8309006 | 0.82 | HSD11B1 (0.49) | CA12CA1CA2CA9HSD11B1 | |
| SCHEMBL7662050 | 0.82 | HTR2A (0.47) | LSSKDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL7654098 | 0.75 | L3MBTL1 (0.45) | KDM4EL3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9513674 | 0.74 | KDM4E (0.59) | KDM4EL3MBTL1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6980932 | 0.74 | LSS (0.77) | LSSGAAALDH1A1 | |
| SCHEMBL6977994 | 0.74 | LSS (0.93) | LSSL3MBTL1HPGDALDH1A1TSHR | |
| SCHEMBL4719330 | 0.73 | LSS (0.57) | LSSKDM4EKMT2AMEN1 | |
| SCHEMBL8311310 | 0.73 | GPR119 (0.51) | LSSHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |