Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306216 | 0.84 | CYP3A4 (0.39) | CYP3A4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8306215 | 0.83 | EPHX2 (0.45) | CYP3A4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8306597 | 0.82 | ABCB1 (0.42) | MEN1KMT2AKDM4EBRD4MAOA | |
| SCHEMBL8304673 | 0.79 | BRD4 (0.40) | CYP3A4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8431005 | 0.77 | HPGD (0.50) | CYP3A4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8307532 | 0.77 | L3MBTL1 (0.39) | CYP3A4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8306914 | 0.74 | CYP1B1 (0.43) | CYP3A4MEN1KMT2AMAPTUSP2 | |
| SCHEMBL8427269 | 0.74 | EGFR (0.43) | CYP3A4KDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL8307688 | 0.73 | MAPT (0.35) | CYP3A4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8310185 | 0.72 | MAOB (0.41) | CYP3A4MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| US-5629339-A | CHRONIC VENOUS INSUFFICIENCY | ADIR ET COMPAGNIE (FR) | 1997-05-13 | — | — | US | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |