Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 9/20 | 0.38 |
| ▸ | MTTP | P55157 | 6/20 | 0.37 |
| ▸ | APOB | P04114 | 3/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309546 | 0.91 | FYN (0.47) | SMOMTTPAPOBFYNHDAC1 | |
| SCHEMBL8306217 | 0.89 | SMO (0.40) | SMOMTTPAPOBFYN | |
| SCHEMBL8309243 | 0.89 | MTTP (0.45) | SMOMTTPAPOBFYNMEN1 | |
| SCHEMBL8307723 | 0.85 | DRD2 (0.32) | SMOMTTPAPOB | |
| SCHEMBL8309952 | 0.85 | SMO (0.38) | SMOMTTPAPOBFYN | |
| SCHEMBL8306272 | 0.85 | SMO (0.38) | SMOMTTPAPOBFYNMEN1 | |
| SCHEMBL8307994 | 0.84 | SMO (0.39) | SMOMTTPAPOBMEN1KMT2A | |
| SCHEMBL8310235 | 0.83 | GRIN2B (0.49) | SMOMTTPAPOBFYN | |
| SCHEMBL8305510 | 0.78 | CA12 (0.34) | — | |
| SCHEMBL8305839 | 0.78 | GRIN2B (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759027-B1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | ASTRA AB (SE) | 1999-08-04 | — | — | EP | claimed |