Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.36 |
| ▸ | RXRA | P19793 | 12/20 | 0.35 |
| ▸ | RXRG | P48443 | 6/20 | 0.35 |
| ▸ | RXRB | P28702 | 5/20 | 0.35 |
| ▸ | RARG | P13631 | 7/20 | 0.35 |
| ▸ | RARB | P10826 | 6/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908201 | 0.72 | ACHE (0.53) | RARARXRARXRGRXRBRARB | |
| SCHEMBL8809982 | 0.71 | HIF1A (0.41) | RARARXRARXRGRXRBRARG | |
| SCHEMBL3061673 | 0.69 | RXRA (0.39) | RARARXRARXRGRXRBRARG | |
| SCHEMBL31294415 | 0.68 | RARA (0.36) | RARARXRARXRGRXRBRARG | |
| SCHEMBL3081827 | 0.68 | KDM4E (0.59) | HSD17B1ACHEKMT2A | |
| SCHEMBL3079250 | 0.68 | KDM4E (0.59) | HSD17B1ACHEKMT2A | |
| SCHEMBL3069771 | 0.68 | KDM4E (0.59) | HSD17B1ACHEKMT2A | |
| SCHEMBL6913758 | 0.68 | MAOA (0.42) | RARARXRARXRGRXRBRARG | |
| SCHEMBL8810467 | 0.67 | CDC25B (0.41) | RARARXRARXRGRXRBRARG | |
| Hydrochloric Acid SCHEMBL4219941 | 0.67 | RARA (0.33) | RARARXRARXRGRXRBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933350-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0933351-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0800504-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020914-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-07-11 | — | — | WO | disclosed |