SCHEMBL831081

SCHEMBL831081

O=C1N=CC2c3ccccc3Oc3cccc1c32

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
ATM Q13315 1/20 0.36
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34
NISCH Q9Y2I1 1/20 0.34
CYP2C9 P11712 1/20 0.33
MAPT P10636 2/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL855337 0.73 MAOA (0.37) MAOAMAOBATMHDAC3HDAC4
SCHEMBL4685836 0.70 ALDH1A1 (0.46) MAOBMAPTMEN1KMT2ALMNA
SCHEMBL7142349 0.67 LMNA (0.39) MAOAMAOBATMHDAC3HDAC4
SCHEMBL7144469 0.67 NISCH (0.40) MAOAMAOBATMHDAC3HDAC4
SCHEMBL18954022 0.66 ALDH1A1 (0.36) MEN1KMT2AKDM4EALDH1A1
SCHEMBL16655976 0.66 ALDH1A1 (0.40) MAOAMAOBHDAC3HDAC4HDAC7
SCHEMBL217432 0.66 PARP1 (0.40) MAOAMAOBATMNISCHMAPT
SCHEMBL29802419 0.66 PARP1 (0.40) MAOAMAOBATMNISCHMAPT
SCHEMBL30312068 0.66 PARP1 (0.40) MAOAMAOBATMNISCHMAPT
SCHEMBL1477932 0.65 TRPA1 (0.42) MAOAMAOBATMHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250381221-A1 Compositions and Methods for Treating Cancer IN8BIO INC (US) 2025-12-18 US disclosed
US-20250161247-A1 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS LANTERN PHARMA INC. (US) 2025-05-22 US disclosed
US-20240299322-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES LANTERN PHARMA INC. (US) 2024-09-12 US disclosed
US-20240245643-A1 DNA Damage Repair Inhibitors for Treatment of Cancer THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2024-07-25 US disclosed
EP-4376822-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES Lantern Pharma Inc. (US) 2024-06-05 EP disclosed
WO-2024016014-A2 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS LANTERN PHARMA INC. (US) 2024-01-18 WO disclosed
WO-2023010119-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES LANTERN PHARMA INC. (US) 2023-02-02 WO disclosed
US-20220339179-A1 TREATMENT OF HR DEFICIENT CANCER THE FRANCIS CRICK INSTITUTE LIMITED (GB) 2022-10-27 US disclosed
EP-4028009-A1 TREATMENT OF HR DEFICIENT CANCER The Francis Crick Institute Limited (GB) 2022-07-20 EP disclosed
US-11162095-B2 Use of a combination of Dbait molecule and PARP inhibitors to treat cancer INSTITUT CURIE (FR) 2021-11-02 US disclosed
US-20120135983-A1 DNA Damage Repair Inhibitors for the Treatment of Cancer The Institute of Cancer Reseach 2012-05-31 US disclosed
US-8143241-B2 DNA damage repair inhibitors for treatment of cancer KUDOS PHARMACEUTICALS LIMITED (GB) 2012-03-27 US disclosed
EP-1684736-B1 DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANCER KUDOS PHARM LTD (GB) 2011-08-24 EP disclosed
WO-2011058367-A2 DIAGNOSTIC TEST FOR PREDICTING RESPONSIVENESS TO TREATMENT WITH POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITOR ASTRAZENECA AB (SE) 2011-05-19 WO disclosed
EP-2305221-A1 Dna damage repair inhibitors for treatment of cancer Kudos Pharmaceuticals Limited (GB) 2011-04-06 EP disclosed
US-20100249112-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS ASTRAZENECA R&D (SE) 2010-09-30 US disclosed
EP-2167086-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS AstraZeneca AB (SE) 2010-03-31 EP disclosed
WO-2008146035-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS ASTRAZENECA AB (SE) 2008-12-04 WO disclosed
US-20060142231-A1 DNA damage repair inhibitors for treatment of cancer KUDOS PHARMACEUTICALS LIMITED (GB) 2006-06-29 US disclosed
US-20050227919-A1 DNA damage repair inhibitors for the treatment of cancer KUDOS PHARMACEUTICALS LIMITED 2005-10-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250161247-A1 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS PARP1, PARP2, PARP3 MAOA 2310/4885MAOB 2213/4885ATM 1060/4885
US-11162095-B2 Use of a combination of Dbait molecule and PARP inhibitors to treat cancer PARP10, PARP1, PARP3 MAOA 2564/4885MAOB 2454/4885ATM 227/4885
US-20240299322-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES PARP1, PARP2, PARP11 MAOA 2908/4885MAOB 2942/4885ATM 658/4885
US-20120135983-A1 DNA Damage Repair Inhibitors for the Treatment of Cancer MRE11, ERCC4, PARP2 MAOA 3869/4885MAOB 2811/4885ATM 88/4885
US-20240245643-A1 DNA Damage Repair Inhibitors for Treatment of Cancer PARP2, MRE11, PARP1 MAOA 3899/4885MAOB 2826/4885ATM 96/4885
US-20060142231-A1 DNA damage repair inhibitors for treatment of cancer MRE11, PARP2, ERCC4 MAOA 3848/4885MAOB 2738/4885ATM 89/4885
US-20100249112-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS CHEK1, CHEK2, PARP1 MAOA 4590/4885MAOB 4319/4885ATM 96/4885
US-20050227919-A1 DNA damage repair inhibitors for the treatment of cancer MRE11, ERCC4, PARP2 MAOA 3869/4885MAOB 2811/4885ATM 88/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.