Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312682 | 0.89 | KMT2A (0.43) | ALDH1A1KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL8316536 | 0.89 | MEN1 (0.32) | ALDH1A1KMT2AMEN1SMN1; SMN2NLRP3 | |
| SCHEMBL8317256 | 0.86 | ALDH1A1 (0.39) | ALDH1A1MAPTGLAHPGDKMT2A | |
| SCHEMBL8316864 | 0.85 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8318118 | 0.84 | ALDH1A1 (0.45) | ALDH1A1MAPTGLAHPGDKMT2A | |
| SCHEMBL8317855 | 0.83 | KMT2A (0.34) | ALDH1A1MAPTGLAHPGDKMT2A | |
| SCHEMBL8313747 | 0.83 | ALDH1A1 (0.35) | ALDH1A1MAPTHPGDKMT2AMEN1 | |
| SCHEMBL8878145 | 0.81 | KMT2A (0.41) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8314030 | 0.81 | SMN1; SMN2 (0.36) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL8313446 | 0.81 | KMT2A (0.37) | ALDH1A1MAPTHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |