Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317102 | 0.89 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8314373 | 0.88 | MEN1 (0.32) | KMT2AMEN1SMN1; SMN2ALDH1A1NLRP3 | |
| SCHEMBL8312985 | 0.83 | ALDH1A1 (0.34) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8316234 | 0.82 | HSD11B1 (0.33) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8316864 | 0.81 | ALDH1A1 (0.38) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8877115 | 0.81 | KMT2A (0.39) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8313464 | 0.81 | NLRP3 (0.33) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8316807 | 0.81 | SMN1; SMN2 (0.37) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL8317256 | 0.80 | ALDH1A1 (0.39) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8317229 | 0.79 | KMT2A (0.38) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |